Basic Information
VIS ID
TVIS10015240
Fusion event
HBV-KAZN integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp4 precore/core protein
Start
2386
Orient
-
Integrated sequence
CCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCT| |CGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTA
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
14860398/14533902 (Hg38)
End
14860398/14533902 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
KAZN
Nearest miRNA
hsa-mir-12136/Upstream/1954879; hsa-mir-101-1/Downstream/2325047;
Nearest TSS
ENST00000473358/Upstream/142327; ENST00000376028/Downstream/64802;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/640660, chr1-CpG: 116/Downstream/64212
Upstream sequence
ATTTTTGTTGGGAGACTTAAGCAAACAGTACCTTGATTATTCTCTAATTCTTTGACCTGTCTGCTCACATACAAGAGTCAGGGTTATAGAAGGAATCTGA
Downstream sequence
GGGATTATTATCCAAACTTGCAAAGAAACATCCTTGCCTCTCTGACTGCATCCCCAGCTAATAAAGATAGGCACTCATAAAGTTTATAAATGATCTCAAA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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