Basic Information
VIS ID
TVIS10015252
Fusion event
HBV-LOC105375631 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1820
Orient
+
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
End
90411435/89399206 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-12123/Upstream/9157733; hsa-mir-10400/Downstream/1806279;
Upstream sequence
GCAGGGCAGCTTTTGCTGGACAGCAAAAGGACCCACCTGCACAGCTACCAAAGTGCTCTATGTATATTTTAAGAAGGCTCGTCTCAAATTCAACAAATGC
Downstream sequence
AAGATTCTGTTGGTTTGTTTTAATTTTATTCTTTATCTGGAATTATAGTAGTAATCTATTCATTCTGTAAATATTCAAGGCAAAAGAAGAATCTAAAGTA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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