Basic Information
VIS ID
TVIS10015253
Fusion event
HBV-LOC105375631 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp3 X protein
Start
1468
Orient
-
Integrated sequence
CGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCG| |GGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCAT
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
90412055/89399826 (Hg38)
End
90412055/89399826 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105375631
Nearest miRNA
hsa-mir-12123/Upstream/9158353; hsa-mir-10400/Downstream/1805659;
Nearest TSS
ENST00000518652/Upstream/590918; ENST00000517696/Downstream/217331;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1071574, chr8-CpG: 92/Downstream/357481
Upstream sequence
gatgagtatttcaagcatgaagTATCAATACTAACAGCAATAAGTAAATTGGATTTAGCTTTTAAAAGCTCTTTGGTGGTACCCTTTTTTAAAAAAAATT
Downstream sequence
ACTTTATTTATATACAGCTCTGTATAAAATACATGGTTGGATTTTTTTAATCGAATCTACTTTTTTTCTAATAATCAGTGAACCTCTTCATTTTCATTGA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate