RSPO2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015255
Fusion event
HBV-RSPO2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2222
Orient
+
Integrated sequence
TTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTG| |TCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTA
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
109079440/108067212 (Hg38)
End
109079440/108067212 (Hg38)
Orient
+
Location type
Intronic
Target gene
RSPO2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-15a-3p
Nearest miRNA
hsa-mir-12123/Upstream/3582747; hsa-mir-10400/Downstream/4576281;
Nearest TSS
ENST00000518652/Upstream/69958; ENST00000520037/Downstream/5877;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1408849, chr8-CpG: 92/Downstream/15415
Upstream sequence
gagtgcaaactgaattttaattcactttttaatttccagaagacagcacagcatccagcacataattacttactaaatgCAGGAAATATGACACACGGAT
Downstream sequence
tttcaatgctgattcaagcatagccactgtataaagacatttttgaggcaattggggaaatccattacataccgattattaagaggtgctatcaagaaat
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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