Basic Information
VIS ID
TVIS10015260
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
4588164/4566934 (Hg38)
End
4588164/4566934 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/710793; hsa-let-7a-2/Downstream/2667832;
Nearest TSS
ENST00000527297/Upstream/21743; ENST00000641486/Downstream/10886;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/379011, chr11-CpG: 34/Downstream/40934
Nearby gene
C11orf40(No orient, 4488)
Upstream sequence
TGGACGAATCTTAGAAGGGCCTATTAGAATCAAAGTTGAACATACAGGGTTAAGAGCAGCTTTTAAAGACTGAGTTCTAAGCATCCCCAAAACTTTCTAG
Downstream sequence
GTGTGAGGTTTGTGGCAAACTAGCGTAACTGCTAGCTCCTTTTTACCAAGGTCAGTCTGAGAAGTACCACCTGTACAAAAACACAAATTAGACTTCGAAG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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