Basic Information
VIS ID
TVIS10015261
Fusion event
HBV-chr16 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
256
Orient
-
Integrated sequence
ATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACT| |CGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCC
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
27195945/27184624 (Hg38)
End
27195945/27184624 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA16E
Nearest miRNA
hsa-mir-1225/Upstream/1159314; hsa-mir-11401/Downstream/1206358;
Nearest TSS
ENST00000527434/Upstream/8037; ENST00000563881/Downstream/18871;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/74564, chr16-CpG: 82/Downstream/18827
Upstream sequence
ccccaactctaaaaaatgaaataaaaaaTGATCCCAAGAGTTCAAAGGTTTAACATAGCAAATGTTGTGCATCCAGCATGGGCTGACGGAAGGCTCTGCT
Downstream sequence
TCACTCAGAGACTCGGGCAGAGGGAGATGTcctgagactgggtaatttataaggaaaagaggtttaattggctcatggttccacaggacatacaggaagc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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