Basic Information
VIS ID
TVIS10015263
Fusion event
HBV-chr22 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
644
Orient
+
Integrated sequence
GAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATG| |GGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGG
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
37997820/37601813 (Hg38)
End
37997820/37601813 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1286/Upstream/1314906; hsa-let-7a-3/Downstream/242459;
Nearest TSS
ENST00000624155/Upstream/19197; ENST00000488672/Downstream/6662;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/35001, chr22-CpG: 85/Downstream/6623
Nearby gene
GGA1(+6661) ;
Upstream sequence
AACACGGGGCAGTATTTGCATATTGTCTTCCCATTGATGAAATCCGCTGTCTCTAGTTTCCTTCTGGCCAGTGGGGTAAGGGCATAGTATCCGCCTCAGT
Downstream sequence
GTCCACGCCCCTGTAATTTACATCTTCCTACCCAATGAAAAGGTGTCCGGGGGTGGGGAAAAGGGAGTTGCTCAGACTCTTCATTCCCCAGCCCCTTCTG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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