Basic Information
VIS ID
TVIS10015269
Fusion event
HBV-chr16 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1941
Orient
-
Integrated sequence
CATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTG| |GAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGC
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
32720350/32709029 (Hg38)
End
32720350/32709029 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/1815044; hsa-mir-11401/Downstream/1454549;
Nearest TSS
ENST00000527434/Upstream/32297; ENST00000569859/Downstream/32065;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/20851, chr16-CpG: 65/Downstream/17442
Upstream sequence
TTTGTGAATGGAAATGTAGCAGGGCTTTTGCCTTTTTTCCTTGTTCATGAAAAACAAGTCGCGCTTGGGGAGCAAGTATTCCCGTTCAACTGCTGTCACT
Downstream sequence
CATTCTTAGCTCTGTTTAGAAGAAATAAGCACAGATGGTTGGTCTACTACTTCCCCAACGAAAAATTTGCCTGTTggctgggcgcggtggctcacgcctg
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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