Basic Information
VIS ID
TVIS10015272
Fusion event
HBV-chr6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2482
Orient
-
Integrated sequence
CCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAAC| |TTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAAT
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
43832278/43864541 (Hg38)
End
43832278/43864541 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
LOC105375068 ; LOC107986598
Nearest miRNA
hsa-mir-10398/Upstream/429921; hsa-mir-10524/Downstream/389665;
Nearest TSS
ENST00000381078/Upstream/12208; ENST00000448947/Downstream/136039;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/92426, chr6-CpG: 94/Downstream/137646
Upstream sequence
tcgcttgaacccaggaggcagaggttgcagtgagcggagattgtgccattgcactccagcctgggcaacaagaacgaaactccatctcaaaaaaaaatta
Downstream sequence
CCCTGATGAGGTCGGTGGGGTCATGATCTGTCTGTCAGACTCTGCAGAACCTGGGCAGACTTCTCCTCTCtgcctaggcagagagcacccagatggggat
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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