Basic Information
VIS ID
TVIS10015273
Fusion event
HBV-chr9 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
169
Orient
+
Integrated sequence
TCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCA| |CATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTC
Host Sequence
Chromosome
chr9
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
14938350/14938352 (Hg38)
End
14938350/14938352 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/8930448; hsa-let-7a-1/Downstream/3634954;
Nearest TSS
ENST00000422679/Upstream/27357; ENST00000461041/Downstream/249713;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/244774, chr9-CpG: 41/Downstream/39744
Nearby gene
FREM1(No orient, 27356)
Upstream sequence
ggtttagtgccttgcccaaagtcacacaATATATTGATGTTCAAGACAAGAGGAAAACTTGGGATTTATAATGTATAGACCAGCAATGGTTCTACCCTCT
Downstream sequence
ttgaatattaatataatattGATATCAAGTATTTTGATGTATATGTTGatattaatatatgtatataaattaacatattgatcaaatattaatatgttga
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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