VISDB Viral Integration Site DataBase

VIS ID

TVIS10015291

Fusion event

HBV-ROCK1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

1644

End

1757

Orient

-

Integrated sequence

CAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAG

Chromosome

chr18

Cytoband

p11.32

Reference genome

Start

End

109965/109965 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-146a-5p ; hsa-mir-584-5p ; hsa-mir-124-3p ; hsa-mir-1280 ; hsa-mir-148b-3p ; hsa-mir-335-5p ; hsa-mir-148a-3p ; hsa-mir-135a-5p ; hsa-mir-145-5p ; hsa-mir-340-5p ; hsa-mir-4662a-5p ; hsa-mir-4753-5p ; hsa-mir-6507-5p ; hsa-mir-6768-3p ; hsa-mir-548aw ; hsa-mir-5093 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3688-3p ; hsa-mir-300 ; hsa-mir-506-3p ; hsa-mir-584-3p ; hsa-mir-126-3p ; hsa-mir-144-5p

Nearest miRNA

hsa-mir-1-2/Downstream/2291;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/33673, chr18-CpG: 21/Downstream/2344

Nearest cancer related gene

ROCK1(OG, No orient, 0)

Upstream sequence

tcttgtttaggctctgcctactggagacattgtgacatatctccgcactgatcacccaggtgatgtcacttttgtcaaggatatggctacagggacattg

Downstream sequence

ggcatagtgacatatctctgcactgatcactcatgtgatgtaacgcttgtctaagctgcgcctaaaggcgaattgtgacagatatctccactgatcaccc

Target sequence

tgacatatctctgcactgatcacccaggtgatgtaacccttgtctaggctctgccaaaagggggcattgtgacataactctgcactgatcacccaggtgatgggactcttgtctaggctctgcctacaggggcattgtgacatatctctgcagtgatcacgcaggtgatgtaactcttgtctatatctgtctactggtggcattgtggcatatttctgcactgatcacccaggtgatggactcttgtcttggatc