Basic Information
VIS ID
TVIS10015588
Fusion event
HBV-KMT2C integration
Validated
No
Detection method
MAPS
Data source
Curated
Sample type
Adjacent tissue
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2012
PubMed ID
23236287
Virus Sequence
Virus name
HBV
Reference genome
AY800389.1;AY800390.1;AY800391.1;AY800392.1
Orient
+
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
151934960/152237875 (Hg38)
End
151934960/152237875 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/804236; hsa-mir-153-2/Downstream/5336461;
Nearest TSS
ENST00000635602/Upstream/15808; ENST00000564834/Downstream/1194;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/106318, chr7-CpG: 31/Downstream/128874
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
GCATTTCATGTTCAAGAAAATAAATTGAGAGATT
Junction sequence
GCATTTCATGTTCAAGAAAATAAATTGAGAGATTAATTTATGCCTACAGCCTCCTAGTACAAAGACCTTTAACCTAATCTCCTCCCCC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ding, D., et al. Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet ,2010,8(12): e1003065.
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