ERBB4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015613
Fusion event
HBV-ERBB4 integration
Validated
No
Detection method
MAPS
Data source
Curated
Sample type
Adjacent tissue
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2012
PubMed ID
23236287
Virus Sequence
Virus name
HBV
Reference genome
AY800389.1;AY800390.1;AY800391.1;AY800392.1
Orient
+
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
213009434/212144709 (Hg38)
End
213009434/212144709 (Hg38)
Orient
+
Location type
Intronic
Target gene
ERBB4
miRNAs that regulate target gene
hsa-mir-372-3p ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-146a-5p ; hsa-mir-145-5p ; hsa-mir-221-3p ; hsa-mir-302b-3p ; hsa-mir-193a-3p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-10b/Upstream/4389828; hsa-mir-1244-1/Downstream/281554;
Nearest TSS
ENST00000437798/Upstream/19528; ENST00000434559/Downstream/284538;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1667897, chr2-CpG: 86/Downstream/392747
Nearest cancer related gene
ERBB4(TSG, No orient, 0)
Upstream sequence
AGAAATGATAAAAACAAAATTTGAGGTCTCCA
Downstream sequence
TCAAAACTAGTCAAAG
Junction sequence
AGAAATGATAAAAACAAAATTTGAGGTCTCCATACAGACTCCTAGTACAAAGATCATTAACCTAATATCCTATCAAAACTAGTCAAAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ding, D., et al. Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet ,2010,8(12): e1003065.
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