Basic Information
VIS ID
TVIS10015697
Fusion event
HBV-SOX2-OT integration
Validated
No
Detection method
MAPS
Data source
Curated
Sample type
Adjacent tissue
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2012
PubMed ID
23236287
Virus Sequence
Virus name
HBV
Reference genome
AY800389.1;AY800390.1;AY800391.1;AY800392.1
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37/hg19
Start
181097670/181379882 (Hg38)
End
181097670/181379882 (Hg38)
Orient
-
Location type
Intronic
Target gene
SOX2-OT
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-let-7g/Upstream/4864731; hsa-mir-1224/Downstream/2506918;
Nearest TSS
ENST00000440867/Upstream/390108; ENST00000325404/Downstream/62604;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/390043, chr3-CpG: 100/Downstream/315344
Upstream sequence
CTCTGCATGTTGTGGGCCACCATTTATTTTTGATA
Junction sequence
CTCTGCATGTTGTGGGCCACCATTTATTTTTGATATATGCCTACAGCCTCCTAATACAAAGACCTTTAACCTAATCTCCTCCCCCAAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ding, D., et al. Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet ,2010,8(12): e1003065.
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