Basic Information
VIS ID
TVIS10015726
Fusion event
HBV-ARHGAP45 integration
Validated
No
Detection method
MAPS
Data source
Curated
Sample type
Adjacent tissue
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2012
PubMed ID
23236287
Virus Sequence
Virus name
HBV
Reference genome
AY800389.1;AY800390.1;AY800391.1;AY800392.1
Orient
-
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1085392/1085393 (Hg38)
End
1085392/1085393 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ARHGAP45
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1302-11/Upstream/271740; hsa-let-7e/Downstream/730766;
Nearest TSS
ENST00000633603/Upstream/2454; ENST00000614791/Downstream/4537;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1962, chr19-CpG: 16/Downstream/7831
Upstream sequence
ACCTCCAGGATTCAACCATCCTCCACCAGCTCCCTCCCACAACACGTGGGAATTATGGGAGCTACAAGCTGAGGTT
Junction sequence
ACCTCCAGGATTCAACCATCCTCCACCAGCTCCCTCCCACAACACGTGGGAATTATGGGAGCTACAAGCTGAGGTTTGGTCGCCATGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ding, D., et al. Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet ,2010,8(12): e1003065.
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