Basic Information
VIS ID
TVIS10015874
Fusion event
HBV-chr18:q21.31 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1838
Orient
-
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
56110442/58443210 (Hg38)
End
56110442/58443210 (Hg38)
Orient
+
Fragile sites / regions
FRA18B
Nearest miRNA
hsa-mir-1-2/Upstream/2963912; hsa-mir-122/Downstream/7864;
Nearest TSS
ENST00000575820/Upstream/26445; ENST00000590797/Downstream/3065;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/186374, chr18-CpG: 92/Downstream/227769
Nearby gene
MIR122
Nearest cancer related gene
MIR122(TSG, No orient)
Upstream sequence
CTGCTGACCTTGAAATCCTCTGGTTATTGAGAATGTGGCAGGTAGAGAACATTAGTGTTATGTACAGTTGAAACTAAATGAAGAAACTGCACATTTAATC
Downstream sequence
TCTGAATATACACATTAGGGATTGAGACATTCTAAATTAAACTTCAACCTTCCAAGATTCACATCTACCTTATTTTTTAAAAAGGCACTCATCTTTATTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate