GTF2I _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015877
Fusion event
HBV-GTF2I integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1826
Orient
-
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
74113982/74699652 (Hg38)
End
74113982/74699652 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA7J
Target gene
GTF2I
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/103626; hsa-mir-10399/Downstream/1215545;
Nearest TSS
ENST00000635602/Upstream/14995; ENST00000490431/Downstream/5525;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/40900, chr7-CpG: 124/Downstream/88337
Upstream sequence
ATGGTACAGAGATATGTTGGAAAGCACATTTGTAGTCACCAAGCAGTAAACAACTCTCACATGCTGACTCACAAGCACATCATACTACTtgtcacgtgtg
Downstream sequence
TTTCTTACTCTTGTCACATCATAAAACAAAGCTCTTACAAGAAAACAGTCAAAGGAGGAGATTGAGGTTTTACTGCAGGGTCATAGGTGAAAATCAATTC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate