Basic Information
VIS ID
TVIS10015889
Fusion event
HBV-ENTR1 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1826
Orient
+
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
139300273/136405821 (Hg38)
End
139300273/136405821 (Hg38)
Orient
-
Location type
Intron
Target gene
ENTR1
miRNAs that regulate target gene
hsa-mir-6739-3p ; hsa-mir-375 ; hsa-mir-3591-5p ; hsa-mir-7156-5p ; hsa-mir-4677-5p ; hsa-mir-4273 ; hsa-mir-561-5p ; hsa-mir-4330 ; hsa-mir-8068 ; hsa-mir-138-1-3p ; hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-4255 ; hsa-mir-6830-5p ; hsa-mir-5582-5p ; hsa-mir-551b-5p ; hsa-mir-142-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1555014; hsa-mir-126/Downstream/113747;
Nearest TSS
ENST00000422679/Upstream/473; ENST00000620412/Downstream/1364;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/5460, chr9-CpG: 27/Downstream/1267
Upstream sequence
GATGCCATACCTTTGAGCCATGTAACTTTGccctccaaccacgactggggtctcagccacgcaacttgctttggccagtaagatattaggaagcatgatt
Downstream sequence
AGCATGGATCATCCATCGTATGAAGTGCTGAGTTGGATGATCAAACAGATCAGCTTATATTTTCCTTGTCTCATTCtaatattattcctacacagacatt
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate