VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10015915

Fusion event

HBV-FBLN5 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

22962577

Virus Sequence

Virus name

HBV

Reference genome

Not given

Start

1757

Orient

-

Host Sequence

Chromosome

chr14

Cytoband

q32.12

Reference genome

GRCh37/hg19

Start

92353742/91887398 (Hg38)

End

92353742/91887398 (Hg38)

Orient

+

Location type

Intron

Target gene

FBLN5

miRNAs that regulate target gene

hsa-mir-200c-3p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-542-3p ; hsa-mir-7-5p ; hsa-mir-7854-3p ; hsa-mir-6770-5p ; hsa-mir-3185 ; hsa-mir-2277-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-4433b-3p ; hsa-mir-3120-3p

Nearest miRNA

hsa-mir-1260a/Upstream/14621108; hsa-mir-1185-1/Downstream/2060828;

Nearest TSS

ENST00000550708/Upstream/9356; ENST00000553427/Downstream/59676;

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/50950, chr14-CpG: 56/Downstream/59839

Upstream sequence

cagccttctcctctgcgcctgtgtctcctgtctgttacagtgacacttaccattggatgtagggcccacccagtcaatctaggatgatctcatctcaaaa

Downstream sequence

TACCACCACCAGGAGACCAGAGTCCCAGGTACCAAGGCTCTCCACCCAGGACCTTTGGGAGCATGATCTTAGATCCAAAAGTGTTCACTTAAGGACCGGG

Reference

Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.