Basic Information
VIS ID
TVIS10015945
Fusion event
HBV-chr17:q25.1 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1805
Orient
+
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
74545780/76549698 (Hg38)
End
74545780/76549698 (Hg38)
Orient
+
Location type
Intronic
Target gene
CYGB ; PRCD
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-297 ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-7705 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4699-5p ; hsa-mir-1245b-3p ; hsa-mir-2392 ; hsa-mir-5683
Nearest miRNA
hsa-mir-10226/Upstream/451622; hsa-mir-1250/Downstream/186752;
Nearest TSS
ENST00000595228/Upstream/2408; ENST00000588104/Downstream/1477;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/11214, chr17-CpG: 76/Downstream/7440
Nearby gene
PRCD
Nearest cancer related gene
CYGB(TSG, No orient, 0)
Upstream sequence
atggtccacccgccttggcctcccaaagtgctgtgattacaggcttgagccatcgcatccagccccacagttaatacttaatgatgaaagactgtaagtt
Downstream sequence
aacacactgagatatataaagatagaataatactcagcaatgaaaaggaaatgaactgctgatgccgacgacatgggtaaattgagagaagccagacaca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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