EIF4B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015965
Fusion event
HBV-EIF4B integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1826
Orient
-
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
53412457/53018673 (Hg38)
End
53412457/53018673 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA12A
Target gene
EIF4B
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-16-5p ; hsa-mir-23b-5p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/119689; hsa-let-7i/Downstream/38271;
Nearest TSS
ENST00000382841/Upstream/12189; ENST00000550025/Downstream/187;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/11561, chr12-CpG: 106/Downstream/28122
Upstream sequence
TGCTTCCGGGATGAGGTTCCCATTCTCTACACAGCATTGGCATTAGTAGATATATCACCATGACGTACCTTAAAAAAAAGCTGAAATTGCATTTCCCAGC
Downstream sequence
AATCGCCCTCAGTACAGCCTTTATGCATTAGGGTCAGATATAAGGCTGGTGACTAAATTTATCTTCCTTTATTTTTATTCACTTTTCTTGCCTTTTTCTC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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