Basic Information
VIS ID
TVIS10016043
Fusion event
HBV-GCFC2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1711
Orient
-
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
75904474/75677348 (Hg38)
End
75904474/75677348 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA2S
Target gene
GCFC2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-10a-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-1273e ; hsa-mir-6807-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-2467-3p ; hsa-mir-6894-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-605-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714 ; hsa-mir-1252-5p ; hsa-mir-150-3p ; hsa-mir-4762-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p ; hsa-mir-532-5p ; hsa-mir-5589-3p ; hsa-mir-5683
Nearest miRNA
hsa-mir-1285-2/Upstream/586434; hsa-mir-10b/Downstream/3971946;
Nearest TSS
ENST00000437798/Upstream/7134; ENST00000604464/Downstream/10544;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/30054, chr2-CpG: 64/Downstream/33183
Upstream sequence
tctgggtgctggtcttgtggtgtgttcactttataagaattcaAATTCACTGAACTCAGTGCTTACGATGGCACACACTTCAGTGCGCCAATGAAGTTTT
Downstream sequence
AATGGAGTGATCCCACTGGTGAACTGTCTTAGCAACATGGGGCATTATATAGTGTAagtgattctctaccaagtgccattttgccatccctagggaatac
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate