Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016052
Fusion event
HBV-UBE4B integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1354
Orient
+
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
Start
End
10126993/10066935 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-3p ; hsa-mir-92a-3p ; hsa-mir-6885-3p ; hsa-mir-3926 ; hsa-mir-1251-3p ; hsa-mir-4753-5p ; hsa-mir-9-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-6870-5p ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4668-5p ; hsa-mir-3202 ; hsa-mir-3148 ; hsa-mir-3179 ; hsa-mir-873-5p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6783-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-2681-5p ; hsa-mir-607 ; hsa-mir-29b-2-5p ; hsa-mir-580-3p ; hsa-mir-3671 ; hsa-mir-584-5p ; hsa-mir-6798-3p ; hsa-mir-186-3p ; hsa-mir-4762-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-12136/Upstream/99477; hsa-mir-101-1/Downstream/1962223;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/33589, chr1-CpG: 156/Downstream/143022
Nearest cancer related gene
UBE4B(TSG, No orient, 0)
Upstream sequence
ATGAGAAATTGAGACTACCTGAGCTCCTTCCCTGCTTTAAATGAACCACTAGAGGGGGCAGTGACCTGCTCTGCTGCTGCGCCTGAATTGCACCTGTAGG
Downstream sequence
ATATTAGGGTTAGATGGATCTTAATGACTTCCTGGGCCACCTTCTCCCATTTTCTAAACAAGTCcctaaggctacagacttggtcagtgacaaaactagg
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.