CUL4A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016053
Fusion event
HBV-CUL4A integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1782
Orient
+
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
113916007/113261693 (Hg38)
End
113916007/113261693 (Hg38)
Orient
+
Location type
Intron
Target gene
CUL4A
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-23b-3p ; hsa-mir-106a-5p ; hsa-mir-18a-5p ; hsa-mir-6501-3p ; hsa-mir-196a-3p ; hsa-mir-4696 ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-451b ; hsa-mir-4432 ; hsa-mir-9-5p ; hsa-mir-137
Nearest miRNA
hsa-mir-1267/Upstream/2920664; hsa-mir-4502/Downstream/1227;
Nearest TSS
ENST00000623511/Upstream/15737; ENST00000471046/Downstream/35548;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/45804, chr13-CpG: 29/Downstream/1067
Nearest cancer related gene
CUL4A(OG, No orient, 0)
Upstream sequence
GTTTCTGTTTTATAAAAGAAAGGAAAATCTATTTATATCTATTCTCTTATTTAGCAATATTTAATGTTTTATTGTTAAAGGTCAGTGTGGTAAAACAAAT
Downstream sequence
AGTATAGAAGAAATCATTGAAAAAGAAACAGCACTTAGACAGAAATGCTGTAaaagtggaaaggagaaggtgaaattacttgcaggttagatggttgcat
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate