Basic Information
VIS ID
TVIS10016076
Fusion event
HBV-PPP4R3B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22962577
Virus Sequence
Virus name
HBV
Reference genome
Not given
Start
1750
Orient
+
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
55810492/55583356 (Hg38)
End
55810492/55583356 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PPP4R3B
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-31-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-1301/Upstream/1734151; hsa-mir-10b/Downstream/399611;
Nearest TSS
ENST00000437798/Upstream/9638; ENST00000608113/Downstream/33261;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/63493, chr2-CpG: 79/Downstream/33775
Upstream sequence
AGACTGTTTCTGTGAGGTGCAAGAGGTCTCTGCATTGCAAACATGAAGACCAGACAACACATGGCTGGTTCACTCTTCATGAACACCTTCCCAGTCACTG
Downstream sequence
AGGTTGTTATAAGAAAAAAAAACACTGAGAAAGGATCTTTTCACAGTGAAAAAATCAATCACTGCTTTTCTAAGTCTTAGGTATCAATTAAACAAGAAAT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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