Basic Information
VIS ID
TVIS10016099
Fusion event
HBV-CEP112 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
2227
Orient
+
Integrated sequence
AGTTATAGTGATGATATGGTATTGGGGGCCAAGTCTGTACAACATCTTGAGTCCCTTTATACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATT| |TAAACCCTCATAAAACAAAAAGATGGGGATATTCCCTTAATTTCATGGGATATGTAATTGGGAGTTGGGGCTCCTTGCCACAGGAACATATTGTACAAAA
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
63803653/65807535 (Hg38)
End
63803653/65807535 (Hg38)
Orient
+
Location type
Intronic
Target gene
CEP112
miRNAs that regulate target gene
hsa-mir-331-3p
Nearest miRNA
hsa-mir-10226/Upstream/985433; hsa-mir-1250/Downstream/979537;
Nearest TSS
ENST00000595228/Upstream/56431; ENST00000583775/Downstream/18646;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/245722, chr17-CpG: 84/Downstream/384059
Nearby gene
AXIN2(-245913) ; APOH(+404493) ;
Upstream sequence
acaccccttctgcacaccttgcccgatccatctcttccatttggctgtttctgagttatatcccttataatgaactagtaattataagtaaagcattttc
Downstream sequence
ctggaggactaggagggaaaaatggttttatgggcccctctgctctgtgcagcctggggacatggcaccctgtatcccagcctctctggctccagttgta
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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