Basic Information
VIS ID
TVIS10016100
Fusion event
HBV-chr18 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
1774
End
1795
Orient
-
Integrated sequence
TGTCTGCGGCGTTTTATCATCT
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
66084894/68417657 (Hg38)
End
66084994/68417757 (Hg38)
Orient
+
Fragile sites / regions
FRA18C
Nearest miRNA
hsa-mir-1-2/Upstream/1335971; hsa-mir-548av/Downstream/4435564;
Nearest TSS
ENST00000575820/Upstream/152830; ENST00000577835/Downstream/9273;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/900921, chr18-CpG: 67/Downstream/296940
Upstream sequence
gtaatgttgatagtgttgaagagtggcagattgcccacggcagggccaataccaaatattaacaagcttctaagtttcacttatgtgttaactgagaatc
Downstream sequence
TCAAGTGTACCTCTTTTTCCCTACTGTCCTAGCCCTTGCTGATTTTTCCCAGGAACATCCCTGAACTGGCCTTCCTCAGGTTCTTTACTCAAACGATCCA
Target sequence
TGGTCTAATTAGTGCTAAGGGAATCAGGGTGTAGGACTGATCTGTCTTTTTCAGAAACTAAGAAATTTTAAAAGTGTATCACAGAAAGAAATGAAGCATA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate