Basic Information
VIS ID
TVIS10016103
Fusion event
HBV-LRRC75B integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
2555
Orient
+
Integrated sequence
TATATGCATGTATTCAAGCTAAACAGGCTTTTACTTTCTCGCCAACTTACAAGGCCTTTCTAAGCAAACAGTATCTGAACCTTTACCCCGTTGCTCGGCA| |ACGGCCTGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCTTGGCCATAGGCCATCAGCGCATGCGCGGAACCTTTGTGTCTCCGCTG
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
24982866/24586898 (Hg38)
End
24982866/24586898 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRC75B
Nearest miRNA
hsa-mir-1286/Upstream/1700519; hsa-let-7a-3/Downstream/868748;
Nearest TSS
ENST00000624155/Upstream/3148; ENST00000456869/Downstream/5387;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/30792, chr22-CpG: 79/Downstream/5728
Nearby gene
SNRPD3(-14357) ; GGT1(+16257) ;
Upstream sequence
gggattacaggcgtgagccactgcgcccgggcccaaactgtcactttctaagtgggtggccatgggcaatgctcagaggctcagtttcccctttggtgaa
Downstream sequence
aatgggacgtggttgttgtgaggattaaatgcacacacagtaaggctcttTCTTCATGAACTATTATTTGAAATCTCACTGTGTGCCCAGCATCCCACAC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate