Basic Information
VIS ID
TVIS10016104
Fusion event
HBV-chr22 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
1724
Orient
-
Integrated sequence
CTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACACCCGTGTGTCTTGGCCAAAATTCGCAGTCCCAAATCTCCA| |GTCACTCACCAACTTGTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTGCATCCTGCTGCTATGCCTCAT
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43155314/42759308 (Hg38)
End
43155314/42759308 (Hg38)
Orient
-
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/836011; hsa-let-7a-3/Downstream/2441646;
Nearest TSS
ENST00000624155/Upstream/38010; ENST00000443063/Downstream/72344;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/38193, chr22-CpG: 29/Downstream/10633
Nearby gene
A4GALT(-38438) ; ARFGAP3(+37217) ;
Upstream sequence
GGTCAGCATCCCTGCTCCCCTGCTAGAAAGCCGTCTAGAGTGGAAGAGGAGGAAGGCAGGAGGCGGGGAGCGGGTGCCGTGGGTGTTAGCGGTGCTGCTT
Downstream sequence
CGGGTGGTCTCTGAGGCTGCTTCCCTGCCCACCCTCGGCAATGGTTTCCCTGCGCAGCGGCGCGGAGTCTAGCAGGACCCCCATGGCAGTGTCTGCCCCC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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