Basic Information
VIS ID
TVIS10016106
Fusion event
HBV-ADGRL3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
2280
Orient
+
Integrated sequence
CCTTTATACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTCATAAAACAAAAAGATGGGGATATTCCCTTAATTTCATGGGATAT| |GTAATTGGGAGTTGGGGCTCCTTGCCACAGGAACATATTGTACAAAAAATCAAATTATGTTTTAGAAAACTTCCTGTCAACAGGCCTATTGATTGGAAAG
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62199785/61334067 (Hg38)
End
62199785/61334067 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/411383; hsa-mir-1243/Downstream/4942757;
Nearest TSS
ENST00000502981/Upstream/131925; ENST00000509089/Downstream/94154;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/130984, chr4-CpG: 60/Downstream/2015062
Nearby gene
IGFBP7-AS1(-4128320) ; LPHN3(+163053) ;
Upstream sequence
GGCCCAGCACTGCCTGCCTTGGGCCCCCTTTCTTCTTAAGGAAAGGCCAGAAAAAATGTGTCTCCAAAGTGTTTTGGAATTTGTAAGAACAACCGTCAGA
Downstream sequence
cactacgcttgggtaatttttgtatttttagtagagacagggttttgccatgttggccaggctggtctcaaactcctggcctcaagttatcctcccacct
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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