Basic Information
VIS ID
TVIS10016127
Fusion event
HBV-TMEM272 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
2551
Orient
+
Integrated sequence
CCTTTATATGCATGTATTCAAGCTAAACAGGCTTTTACTTTCTCGCCAACTTACAAGGCCTTTCTAAGCAAACAGTATCTGAACCTTTACCCCGTTGCTC| |GGCAACGGCCTGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCTTGGCCATAGGCCATCAGCGCATGCGCGGAACCTTTGTGTCTCC
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
52418625/51844489 (Hg38)
End
52418625/51844489 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM272
Nearest miRNA
hsa-mir-15a/Upstream/291822; hsa-mir-1267/Downstream/965561;
Nearest TSS
ENST00000623511/Upstream/40192; ENST00000242819/Downstream/661;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/40052, chr13-CpG: 118/Downstream/166689
Nearby gene
DHRS12(-40332) ; CCDC70(+17491) ;
Upstream sequence
actggggtgtaaatcatactgcttccttcactgaggaactcttgctacagaacaaaacagacagctgaacaaaacagtgtgcttgatgCTGGCTGGTGTT
Downstream sequence
TCCCTACCAACATTAGACCAGAACCTCATGCTGGGGAATGTTACTATTCCTCACGTGAAAATGAACATCTCTGAACAGATGATGGGGTGAGATCTTAATT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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