Basic Information
VIS ID
TVIS10016130
Fusion event
HBV-chr15 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
913
Orient
-
Integrated sequence
ATTATGCCTGCTAGATTTTATCCCAATGTTACCAAATACTTGCCCTTAGATAAAGGAATTAAACCCTATTATCCAGAGCATGTAGTTAATCATTACTTCC| |AGACGAGACATTATTTACATACTCTTTGGAAGGCGGGTATCTTATATAAAAGAGAGACGACACGTAGCGCCTCATTTTGCGGGTCACCATATTCTTGGGA
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
70679616/70387277 (Hg38)
End
70679616/70387277 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10393/Upstream/307809; hsa-mir-11181/Downstream/2199940;
Nearest TSS
ENST00000557528/Upstream/65701; ENST00000630100/Downstream/118651;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/286410, chr15-CpG: 56/Downstream/197764
Nearby gene
TLE3(-289360) ; UACA(+267276) ;
Upstream sequence
AGGTCTACACGGACACAGTAACCATTTGGCTGAGCATTTCCTTGTTCTCATTAGTATTTGATACTGATATATCATTTAAATTTTAAAGCGCGAAATCAAG
Downstream sequence
GCAGGCGGAGGGACCAGTGTGTCTACTGCGGCTCCTGCCACCCCAGGGGTCTCCCTTGTTAAGACACCCAGTGGCACCAGCAGACATTTCTCATCCCTAT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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