Basic Information
VIS ID
TVIS10016138
Fusion event
HBV-chr16 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
2338
Orient
+
Integrated sequence
AAAACAAAAAGATGGGGATATTCCCTTAATTTCATGGGATATGTAATTGGGAGTTGGGGCTCCTTGCCACAGGAACATATTGTACAAAAAATCAAATTAT| |GTTTTAGAAAACTTCCTGTCAACAGGCCTATTGATTGGAAAGTGTGTCAACGAATTGTAGGTCTTTTGGGGTTCGCTGCCCCTTTTACACAATGTGGATT
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
78128721/78094824 (Hg38)
End
78128721/78094824 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-1225/Upstream/1225805; hsa-mir-11401/Downstream/3290194;
Nearest TSS
ENST00000527434/Upstream/35370; ENST00000569818/Downstream/4589;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/48555, chr16-CpG: 91/Downstream/4453
Nearby gene
CLEC3A(-62723) ; WWOX(+4829) ;
Nearest cancer related gene
WWOX(TSG, +4829) ;
Upstream sequence
ACAGAAGTGAGACTTCATTTCTGGAGGGGGAGAGGCCAGGGAATGGGTGACCCTCCAGAAGGATGAGCTAGAAAAACAGGGTCTCCCAATAAGCAGGTGT
Downstream sequence
cttactccacatggctgaggaggcctcagaatcatggcgggaggtgaaaggcacttcttccatggtggtggcaagagaaaatgaggacgaagcaaaagtg
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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