Basic Information
VIS ID
TVIS10016139
Fusion event
HBV-chr16 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
214
Orient
-
Integrated sequence
CTGTGGAGTTACTCTCTTTTTTGCCTTCCGACTTCTTTCCTTCTATTCGAGATCTTCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCC| |GGAACATTGTTCACCTCACCATACGGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTAGCCACCTGGGTGGGAAGTAATTTGGAAGAT
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
90003219/89936811 (Hg38)
End
90003219/89936811 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-11401/Upstream/1220474;
Nearest TSS
ENST00000527434/Upstream/13445; ENST00000564836/Downstream/11114;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/963, chr16-CpG: 29/Downstream/11031
Nearby gene
TUBB3(-714) ; DEF8(+11931) ;
Upstream sequence
atgTCtagtctgttttcatgctgctgataaagacctacccgagactgggaagaaaaagaggtttaattggacttacaatttaaaaagagatttaattaga
Downstream sequence
CCGCCCCTTGGAGCTGAGGGGCATCAGCAGCCTCAGTCTCCCAGGTTCTGCCCAGTGGTACCCTGAGAGCGGCCCCTTCTTCTTGAATCACCCTTCAACC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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