VISDB Viral Integration Site DataBase

VIS ID

TVIS10016144

Fusion event

HBV-NEDD4L integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

2650

Orient

+

Integrated sequence

CGGCAACGGCCTGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCTTGGCCATAGGCCATCAGCGCATGCGCGGAACCTTTGTGTCTC| |CGCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGGACTGATAATTCTGTCGTGCTCTCCCG

Chromosome

chr18

Cytoband

q21.31

Reference genome

Start

End

55831619/58164387 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-423-5p ; hsa-mir-7855-5p ; hsa-mir-6807-5p ; hsa-mir-7843-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4786-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-93-3p ; hsa-mir-30a-5p ; hsa-mir-376c-3p

Nearest miRNA

hsa-mir-1-2/Upstream/2685089; hsa-mir-122/Downstream/286687;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/119087, chr18-CpG: 19/Downstream/31034

Nearby gene

ATP8B1(-361292) ; NEDD4L(+31017) ;

Nearest cancer related gene

NEDD4L(TSG, No orient, 0)

Upstream sequence

attaacatcttgcatctgtgtggtatacttgttactattgatgaaccaatattgatatgctattattaactaaaatctatgctttgcattagcattaact

Downstream sequence

TGAAATCTTTTAAAAAACTGTTGTACTTTAGAAGTGCCTCAAGTGACTAATGGAGGCTTAGGACTCTGAGTGGTGTCGCAAGGAACCTTATGCACAGGGA