VISDB Viral Integration Site DataBase

VIS ID

TVIS10016150

Fusion event

HBV-KLK10 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

2758

Orient

-

Integrated sequence

ATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGGACTGATAATTCTGTCGTGCTCTCCCGCAAGTATA| |CGTCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCCTC

Chromosome

chr19

Cytoband

q13.41

Reference genome

Start

End

51520093/51016837 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-224-5p ; hsa-let-7f-5p ; hsa-mir-375 ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-4261 ; hsa-mir-6088 ; hsa-mir-143-3p ; hsa-mir-4770 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-4795-5p ; hsa-mir-1252-5p ; hsa-mir-194-3p ; hsa-mir-140-5p ; hsa-mir-6880-5p ; hsa-mir-6763-5p ; hsa-mir-6825-5p ; hsa-mir-3150a-3p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6077 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-3605-5p ; hsa-mir-4700-5p ; hsa-mir-8089 ; hsa-mir-4667-5p ; hsa-mir-2392

Nearest miRNA

hsa-mir-10395/Upstream/1083700; hsa-let-7e/Downstream/190092;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/13730, chr19-CpG: 65/Downstream/60

Nearby gene

KLK9(-7203) ; KLK11(+5393) ;

Nearest cancer related gene

KLK10(TSG, No orient, 0)

Upstream sequence

CTCATTCTTCAACTAGAGGGAGTACTGTGTTCCTTTGATATAAATCATGGCTTGGCTGTACTCCTTGGCTTCATGATGTTTTCACCAAAACAATTTGTAA

Downstream sequence

GGACCCTGGCTTCTATCCGTTGCAGGCAACCACCTCCTCCTAGAGCTCAAGGAGAATCAGCGGGAGAGGAGTGACGGGCCCAGAAATGCGGAAAAGGACC