Basic Information
VIS ID
TVIS10016170
Fusion event
HBV-chr3 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
2420
End
2447
Orient
+
Integrated sequence
TTTTACACAATGTGGATTTCCTGCTTTA
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
152576680/152858891 (Hg38)
End
152576782/152858993 (Hg38)
Orient
-
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/1292896; hsa-mir-1224/Downstream/6423653;
Nearest TSS
ENST00000440867/Upstream/24198; ENST00000323534/Downstream/302782;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22968, chr3-CpG: 228/Downstream/301486
Upstream sequence
ATAAGAATTCATTCAAgatgaaacttaatgactgctattggtgtgaattgtctcacaaagaaatgccaattctctttgttacccaccttcactatccttc
Downstream sequence
CTGCCAGAAGAGCaaataaataaaaataatgataattttaaataCCACAAATATCTAGAAATCTCAAAATTGCTTTCTTTGCACAATAACAAAACATTTG
Target sequence
GGTTTCTCCACTTATTTGCATATAAATTTACAAAGTATTTCAGCTAGCTCATTGTCTTCTATATTCACTTCATATCAGAAATTTTCAACCATCTCTTTGTAT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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