MECOM _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016175
Fusion event
HBV-MECOM integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
592
Orient
+
Integrated sequence
CTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCACC| |GCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGAAACTTTACGGGGCTTTATTCTTCTACTGTACCTAA
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
169328692/169610904 (Hg38)
End
169328692/169610904 (Hg38)
Orient
-
Location type
Intronic
Target gene
MECOM
miRNAs that regulate target gene
hsa-mir-22-3p
Nearest miRNA
hsa-let-7g/Upstream/1058955; hsa-mir-1224/Downstream/812199;
Nearest TSS
ENST00000440867/Upstream/163037; ENST00000602879/Downstream/52486;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/461279, chr3-CpG: 122/Downstream/50745
Nearby gene
MECOM(-463170) ; TERC(+153705) ;
Nearest cancer related gene
MECOM(OG, No orient, 0)
Upstream sequence
aagcaatgagagacaagggaacatagaccaaatgagataaataTAGCTAATATTTCTAATAAATATATGATGTTAAAATTATTATTAtttttaagacagg
Downstream sequence
GAGTCTGTGTGGGGTAATGATAGGGCTAAGGATGGGACTCTAAACTCAGGTTTCCTCTGTGGGTTTCACAGTTTACTGGTCTTAAGAGGagagtttccta
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate