Basic Information
VIS ID
TVIS10016176
Fusion event
HBV-ADGRL3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
AY033073.1
Start
1581
Orient
+
Integrated sequence
GCCCTGCTCAGAATACTGCCTCTGCCATATCGTCAACCTTCTCGAAGACTGGGGACCCTGTACCGAACATGGAGAACATCGCATCAGGACTCCTAGGACC| |CCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAAAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGA
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62501555/61635837 (Hg38)
End
62501555/61635837 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/713153; hsa-mir-1243/Downstream/4640987;
Nearest TSS
ENST00000502981/Upstream/48469; ENST00000508078/Downstream/259904;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/432754, chr4-CpG: 60/Downstream/1713292
Nearby gene
IGFBP7-AS1(-4430090) ; TECRL(+2642621) ;
Upstream sequence
TCCGTTTGTCCTAGCTTTTCTCTTCTGTCAACCCCACACGCCTTTGGCACAATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTT
Downstream sequence
tgtctttccctctgtgtgtatatgtgtcctaatttcttcttcaaaggacaccaattgtattggaccaggacctaccatatttgtgtatcactgctgcact
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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