Basic Information
VIS ID
TVIS10016178
Fusion event
HBV-CXXC4-AS1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
3185
Orient
-
Integrated sequence
CGACCTTGAGGCATACTTCAAAGACTGTGTGTTTGCTGAGTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTATTAGGAGGCTGTAGGCAT| |AAATTGGTCTGTTCACCAGCACCATGCAAC
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
End
105576742/104655585 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-12113/Upstream/3325171; hsa-mir-1243/Downstream/4833113;
Nearby gene
CXXC4(-164275) ; TET2(+490289) ;
Upstream sequence
AGAATCATTGTAAACGTTTTTTAAATCATTCAGTCATCTATTAGTAATGTACCTTTTTCCTTGGTTCATTAGGTCAAATGCCTCACTGATTTTGTCAAAA
Downstream sequence
aaaatttgaagacattacataaattaagagagtatggcattggcacttggatagacaattaaatcagggcaaaatagagtccagcagcagattgtcacca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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