Basic Information
VIS ID
TVIS10016200
Fusion event
HBV-KAZN integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2278
End
2313
Orient
+
Integrated sequence
TTCGCACTCCTCCAGCTTATAGACCACCAAATGCCC
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
15112955/14786459 (Hg38)
End
15112990/14786494 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
KAZN
Nearest miRNA
hsa-mir-12136/Upstream/2207436; hsa-mir-101-1/Downstream/2072455;
Nearest TSS
ENST00000473358/Upstream/187742; ENST00000376028/Downstream/137636;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/186962, chr1-CpG: 21/Downstream/14593
Upstream sequence
gtaccatttatccagtttcccccagtggtaactgatatggtctggctgtgtccccacccaaatctcatcttgagttgtagctcccataattcccacgtgt
Downstream sequence
TAACCGGGCATGGTGATTTGGCACCTTGAATGGATTGCAAGAAAATCAAGCTCAAATAAGGAGCCACTATAAGCGCATTTCATTTTCATCTGCCATTTAC
Target sequence
TGTGAGCACATAGAGCTGAAACCTCACACTGGGCC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate