Basic Information
VIS ID
TVIS10016202
Fusion event
HBV-chr1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2758
End
2793
Orient
+
Integrated sequence
CTATGGAAGGCGGGTATATTATATAAGAGAGAAACA
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
75270810/74805126 (Hg38)
End
75270845/74805161 (Hg38)
Orient
+
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/3737410; hsa-mir-11399/Downstream/2254982;
Nearest TSS
ENST00000473358/Upstream/41233; ENST00000438619/Downstream/158153;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/606775, chr1-CpG: 40/Downstream/319971
Upstream sequence
GATCTGAAACTCTGCAGACTGTCTATTCAGGCCTGCTTGGCCTTTCTGTTCTCTGGGTGTAGTCAGCCTTTGAGTTTGTATGGATGGAAACTGATagcat
Downstream sequence
tctgcatttctatttcatttagtgtgggctatcagtttttccaagctttcaacagccattctagaacatactagtgttgtctcctagggtccctgccagg
Target sequence
tgctcaccacttgggtcttttaatcccatggcaaa
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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