Basic Information
VIS ID
TVIS10016211
Fusion event
HBV-chr1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2569
End
2695
Orient
+
Integrated sequence
ATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTA
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
235059521/234923774 (Hg38)
End
235059648/234923901 (Hg38)
Orient
-
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/617235; hsa-mir-1537/Downstream/266133;
Nearest TSS
ENST00000473358/Upstream/163718; ENST00000423963/Downstream/33330;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/312496, chr1-CpG: 30/Downstream/180338
Nearby gene
LINC00184(-288995) ; TOMM20(+213136) ;
Upstream sequence
GCAGTGCTCTGCAGGGTCACTGGGTACAACCTTTGTTTGCCAAAGTTAATGATTCACTGAATTGCTCCCACGAGGACTGGAAATCAGGGCTGTGCCTTCC
Downstream sequence
CTCTGCCCGCCCTCCCCACCAGCAAATATCTTCTGTCTCTCATGCTTCCATGCACCACCCCCATGAACACATTTCCCCAGCATAGTGCAACgcacccttg
Target sequence
tggctctccCTGGCGGGCCTCCCCCTCATCCTGCCTCCTGCTGGCCCAGGCCCATCTCATTCCTCATCCCCAGCTACACCAATGCCTGACCTTTCCCAAACACACTGCATCGTCTTGCACAAAGTGT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate