Basic Information
VIS ID
TVIS10016216
Fusion event
HBV-CCNYL2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1794
End
1816
Orient
-
Integrated sequence
ATTGGTCTGCGCACCAGCACCAT
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42956756/42461308 (Hg38)
End
42956882/42461434 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
CCNYL2
Nearest miRNA
hsa-mir-1265/Upstream/6820056; hsa-mir-107/Downstream/536129;
Nearest TSS
ENST00000439456/Upstream/275969; ENST00000429940/Downstream/14109;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/93540, chr10-CpG: 50/Downstream/14313
Upstream sequence
TTTACACACATATTTTTTACCTTTGCTTATTATCCTCTGGAATCTAGAGTTTTtatagcatgttggataaagagaaacagctttgatattactttgctta
Downstream sequence
GGAGTAAAAAACCACAACAATGACTCGGGAGACCAATGTGCCTCCAGAAGAGTCCAGTGGGTCCAGAAGCCCTTTAGATACTGGTCAGAGGTTCCTTTTG
Target sequence
TGAGTGAAGCTGTGAGGTTTCACAATGACATGGCAGCCAATTACATATGCTCAGATGTACCATGTATCAAGAGTTATTCACATAATCAATTAGGCAATATCATTCTACACACAGGCAGTAATAAAG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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