Basic Information
VIS ID
TVIS10016218
Fusion event
HBV-CYP2C23P integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2034
End
2069
Orient
+
Integrated sequence
CCTGAGCATTGTTCACCTCACCATACTGCACTCAGG
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
101878109/100118352 (Hg38)
End
101878144/100118387 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CYP2C23P
Nearest miRNA
hsa-mir-107/Upstream/1193784; hsa-mir-1307/Downstream/856598;
Nearest TSS
ENST00000439456/Upstream/36475; ENST00000443919/Downstream/67642;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2970, chr10-CpG: 43/Downstream/67427
Upstream sequence
GCACTGCACTACATTAGCAATCTTAAGCAACACGACAAGTCAGCTGGGAAATCATGGGCTTCTTCAGGGTCACACAATGCCAGGTATCAACTCTCTTTCT
Downstream sequence
CACTCTTGGGCAAGCATCTCATATATAAAATTTGGGGTTCAGAAGCTCCTCTCCATTTTTAAACTGAAACGAAAGGCTTTGAGTTCTTAAAGGCCTCTCT
Target sequence
CATGGAACCCATGTGTCCTCCATTCCATTAGGGCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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