Basic Information
VIS ID
TVIS10016221
Fusion event
HBV-LINC02646 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2403
End
2438
Orient
+
Integrated sequence
TCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGG
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
132053958/130255694 (Hg38)
End
132053993/130255729 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LINC02646
Nearest miRNA
hsa-mir-107/Upstream/412320; hsa-mir-202/Downstream/706859;
Nearest TSS
ENST00000439456/Upstream/75509; ENST00000439421/Downstream/183338;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/52410, chr10-CpG: 31/Downstream/311692
Upstream sequence
CACTGCTATGTGACTCATTCCACTTCTCTAGGCTTGCTATTTTGTCGTTAACCCATTCTCACCTGTGAAGCCATCTACTCTCTGCTTCACACTATCTTGG
Downstream sequence
GTCTGGATCTCACTTGTATTTGTTTTCTGAATTGACTCTAAATCCTGCAGCTGGCCTGTGCCTGAGCTCCCTGGGGCCCACAGGGGAAGGCAACTGTTGG
Target sequence
CACTTTTTCCTAGTTAATGAAGGAAGAATGGAATT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate