Basic Information
VIS ID
TVIS10016230
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
625
End
785
Orient
+
Integrated sequence
CTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGT
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65478595/65711124 (Hg38)
End
65478753/65711282 (Hg38)
Orient
-
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/61871; hsa-let-7a-2/Downstream/1223152;
Nearest TSS
ENST00000527297/Upstream/48030; ENST00000532042/Downstream/714;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/47516, chr11-CpG: 59/Downstream/596
Nearby gene
RELA(-48152) ; KAT5(+893) ;
Nearest cancer related gene
KAT5(TSG, +893) ;
Upstream sequence
AGGACATCCATGTGCACGGTAAGCTATTTCATTCTGCTTTTACAAATTTCACTAGCAGTGCAGTTGATTGGCAGGCTAATGAGTTTAATTACCAGGCTTG
Downstream sequence
aaaattttaaaaaactagccaggcttggtggtgcgcgcctgtagtcccagctactagagagcctgaggtggatcacttgatcccgggagggggaggctgc
Target sequence
ccggtgacaccttcacagttttgaggagtattcatggggtattttgtaaaatgtttctcaattgggatttgtctgatgtttttctcatgattagactggagGCAgctgggattacaggtgtgagccaccatgcccagtcTCCaaaccctgtttacaca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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