Basic Information
VIS ID
TVIS10016236
Fusion event
HBV-LOC105369468 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1807
End
1827
Orient
+
Integrated sequence
CCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105234870/105364143 (Hg38)
End
105235041/105364314 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369468
Nearest miRNA
hsa-mir-10392/Upstream/1514163; hsa-let-7a-2/Downstream/5983443;
Nearest TSS
ENST00000527297/Upstream/224417; ENST00000527177/Downstream/167383;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1199813, chr11-CpG: 31/Downstream/246085
Upstream sequence
ccgcctcggcctcccaaagtgctgggattataggcgtgagccaccgcgcccagccgttttgtcccattattttagatgccaagaacctgtacaccctcca
Downstream sequence
GAATAAAACTCATATGTCTCGGTCACTCAATAATATATCTTTGGGTCAGGAAATTTTTTTAAATGTGTCTTAAATAGATGAATACTCTTTGCTATAAGAA
Target sequence
GTGCATGAAAAACAGGAATACACTGCACGTGGTATTCTAAAGATTCAATCCAAGAAAAAATAATCAATGAAATCTTACAGAGAATTGAAAGAAGCCAGTTCTTGAAGTCCTCAAATCAATTTATGTCAACTATAATTCAAGGAAGCATCTTAAGTAAAGACAGAATAGGTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate