Basic Information
VIS ID
TVIS10016242
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1682
End
1717
Orient
-
Integrated sequence
TGTCAACGACCGACCTTGAGGCATACTTCAAAGACT
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
91085553/90691776 (Hg38)
End
91085588/90691811 (Hg38)
Orient
+
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/3946627; hsa-mir-1178/Downstream/3869978;
Nearest TSS
ENST00000382841/Upstream/68954; ENST00000549669/Downstream/117465;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/981488, chr12-CpG: 30/Downstream/262216
Nearby gene
LOC102724834(-9434) ;
Upstream sequence
atttggagttttgaccATGGTGATGATACCCCCCATTAGCTAAAACAAAAGCAAAACTAGATGTCAGAGTACCTCGGGGTGAAACAAAACCCCAAATGTA
Downstream sequence
TGCCGTTTTAAACATTCAAGGAGTAATTTCAAAATTTTGCATATTCATATTAAGTTCTGAATCCAATTATAAATAATTGCTTAAATATACTAGAGAAAAG
Target sequence
TATAAAATTTTAAAGGCAAAGGGAATCGGGAAAAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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