Basic Information
VIS ID
TVIS10016243
Fusion event
HBV-chr12 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1752
End
1774
Orient
-
Integrated sequence
GATTAGGTTAAAGGTCTTTGTAC
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
91085697/90691920 (Hg38)
End
91085877/90692100 (Hg38)
Orient
+
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/3946771; hsa-mir-1178/Downstream/3869689;
Nearest TSS
ENST00000382841/Upstream/69098; ENST00000549669/Downstream/117176;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/981632, chr12-CpG: 30/Downstream/261927
Nearby gene
LOC102724834(-9578) ;
Upstream sequence
CAAGCCCATTATCCACATTGTCCCCAGAGTGGTCTTATCAACATGCAGATATGCAATATAAAGATCTTTCCATAATCGAGTTTCTTTGATGCCTCCACAT
Downstream sequence
CATAAGGTATTTACCATGTTGTATTGATCATCACAGGAATATGTTTTTCTGTTCAAACTGGCACAGAGGTCATTAATTTCTAATCTACATAATTTAATTT
Target sequence
TTTCAAATAAAGAAATATTCCCGCTTTATCACCAAATACATTATAATGTTAATCATGAAATCACAAATCATGGAATTTTAAAAGCCCCTTAGCAAACAGATAAAACAATCAGATAAATTTTGATAAATTTAAAAATCTGATGCACTCACCCCTCCCATACCCAGAATATGATAACCCTTC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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